|
KMID : 0369820080380010045
|
|
Jorunal of Korean Pharmaceutical Sciences
2008 Volume.38 No. 1 p.45 ~ p.50
|
|
|
Transdermal Permeation Behavior of 5-FU using Microneedle
|
|
Kim Myoung-Jin
Park Jung-Soo
Kim Yun-Tae
Lee Jun-Hee
Ahn Sik-Il
Park Jong-Hak
Mo Jong-Hyun
Lee Tae-Wan
Lee Han-Koo
Khang Gil-Son
Lee Hae-Bang
|
|
|
Abstract
|
|
|
|
5-Fluorouracil (5-FU) is an antimetabolic of the pyrimidine derivatives that is used in chemotherapy for the treatment of several types of cancer. 5-FU have poor oral absorption and short biological half-time and strong side effects. Microneedle introduced to find a solution of problems. Microneedle device with roll was manufactured for transdermal delivery of various drugs. 5-FU was mixed in non-ionic surfactant such as tween 20 and tween 80. Camscope was used to analysis the permeation magnitude of treated skin by microneedle and trypan blue staining. The 5-FU solution with surfactant measured by ZETA-potential analysis system for stability of solution. The skin permeation rate of 5-FU determined by HPLC. We confirmed that cross treated skin was dyed more deeply than parallel treated skin through trypan blue staining. The results indicate that skin permeation rate of 5-FU was increased with the treatment types and treatment times.
|
|
|
KEYWORD
|
|
|
Transdermal, 5-FU, Tween 20, Tween 80, Microneedle
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|